There exist many different diagrammatic descriptions of 4-manifolds, with the usual claim that "such and such a diagram uniquely determines a smooth 4-manifold up to diffeomorphism". This raises higher order questions: Up to what diffeomorphism? If the same diagram is used to produce two different 4-manifolds, is there a diffeomorphism between them uniquely determined up to isotopy? Are such isotopies uniquely determined up to isotopies of isotopies?
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